Nanomechanics of the endothelial glycocalyx contribute to Na+-induced vascular inflammation
نویسندگان
چکیده
منابع مشابه
Nanomechanics of the endothelial glycocalyx contribute to Na+-induced vascular inflammation
High dietary salt (NaCl) is a known risk factor for cardiovascular pathologies and inflammation. High plasma Na+ concentrations (high Na+) have been shown to stiffen the endothelial cortex and decrease nitric oxide (NO) release, a hallmark of endothelial dysfunction. Here we report that chronic high Na+ damages the endothelial glycocalyx (eGC), induces release of inflammatory cytokines from the...
متن کاملNanomechanics of the Endothelial Glycocalyx in Experimental Sepsis
The endothelial glycocalyx (eGC), a carbohydrate-rich layer lining the luminal side of the endothelium, regulates vascular adhesiveness and permeability. Although central to the pathophysiology of vascular barrier dysfunction in sepsis, glycocalyx damage has been generally understudied, in part because of the aberrancy of in vitro preparations and its degradation during tissue handling. The aim...
متن کاملLoss of the endothelial glycocalyx links albuminuria and vascular dysfunction.
Patients with albuminuria and CKD frequently have vascular dysfunction but the underlying mechanisms remain unclear. Because the endothelial surface layer, a meshwork of surface-bound and loosely adherent glycosaminoglycans and proteoglycans, modulates vascular function, its loss could contribute to both renal and systemic vascular dysfunction in proteinuric CKD. Using Munich-Wistar-Fromter (MW...
متن کاملOligosaccharide model of the vascular endothelial glycocalyx in physiological flow
Experiments have consistently revealed the pivotal role of the endothelial glycocalyx layer in vasoregulation and the layer's contribution to mechanotransduction pathways. However, the exact mechanism by which the glycocalyx mediates fluid shear stress remains elusive. This study employs atomic-scale molecular simulations with the aim of investigating the conformational and orientation properti...
متن کاملDragging along: the glycocalyx and vascular endothelial cell mechanotransduction.
The glycocalyx is a complex and highly dynamic polymeric meshwork that coats the surfaces of most cells and consists of proteoglycans, glycosaminoglycans (GAGs), and glycoproteins, as well as adherent plasma proteins.1,2 In the microvasculature, the glycocalyx layer on the endothelial cell surface plays a critical role in regulating vessel permeability, modulating the dynamics of near-wall move...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Scientific Reports
سال: 2017
ISSN: 2045-2322
DOI: 10.1038/srep46476